Indiana University Southeast is a regional campus in the Indiana University system and is located in New Albany, Indiana, in Floyd County, which is in southern Indiana and part of the metropolitan Louisville, Kentucky, area.
The Indiana University Falls City Area Center was established by Floyd McMurray in 1941 as an extension center of Indiana University in New Albany, Indiana, and Jeffersonville, Indiana. Classes were initially held in classrooms at New Albany High School and Hazelwood Junior High School in New Albany, and at Jeffersonville High School in Jeffersonville. In 1945, IU Southeast moved into its own building in Jeffersonville, named the Indiana University Jeffersonville Extension Center.
As an extension center, IU Southeast's purpose was to permit freshmen and sophomore students to take classes near their residence before transferring to the Indiana University Bloomington main campus. The Indiana University Jeffersonville Extension Center was renamed Indiana University Southeast during 1968. Also, IU Southeast granted its first degrees in 1968. 
IU Southeast moved to its current 177-acre (0.72 km2) campus in New Albany, Indiana, during 1973.
IU Southeast is located 15 minutes north of downtown Louisville, Kentucky, in suburban New Albany, Indiana, at the edge of southern Indiana's picturesque "knobs," which is a region of rolling hills that run parallel to the Ohio River. The campus spreads over 180 acres (0.716 km²) just north of I-265 in Southern Indiana.
IU Southeast is best known for its bachelor's degree programs in business, nursing, and education. The university offers 54 degrees, including 6 master's, 39 bachelor's, and 9 associate's.
IU Southeast is organized into a wide range of special schools and divisions of specialty that include programs from other universities. The five schools include the School of Arts and Letters, School of Business, School of Education, School of Natural Sciences, and the School of Social Sciences. The school had a division of Nursing and a Continuing Studies Division that specialize in those areas. IUS also offers opportunities from other colleges with a branch of the Indiana University Bloomington's School of Public and Environmental Affairs. Additionally, the Indiana University Southeast's medical technology program is affiliated with the University of Louisville's School of Medicine in Louisville, Kentucky through the Kentuckiana Metroversity affiliation of universities and colleges in the Louisville metropolitan area.
Indiana University Southeast broke ground on its residence halls on June 27, 2007. With the addition of residence halls, IU Southeast is the first full-service public institution in the south-central sector of the state. The five lodge-style residence halls are the first on-campus housing at IU Southeast. The lodges feature one, two, and four bedroom units with each bedroom opening to a central living room.
The buildings opened for the fall 2008 semester and now house more than 400 students. The $20.7 million project is a major economic force both locally and across the region. The total impact to the local economy is approximately $44 million and the regional economy gets a boost of nearly $4 million each year.
Due to the success of the first five lodges, the University broke ground for its sixth lodge on April 25, 2012. It is expected to be completed and open for students by fall 2013.
Inidana–Southeast (IUS) teams are known as the Grenadiers. The university competes in the National Association of Intercollegiate Athletics (NAIA) as a member of the Kentucky Intercollegiate Athletic Conference (KIAC). Men's sports include baseball, basketball, cheerleading, dance and tennis; while women's sports include basketball, cheerleading, dance, softball, tennis, and volleyball.
The women’s athletic programs became the IU–Southeast's first accredited athletic program when they became affiliated with the AIAW (Association of Intercollegiate Athletics for Women) in 1975-76. In that same year, there was an attempt to affiliate IU–Southeast with the NCAA's Division III. IU–Bloomington did not approve this, however, on the grounds that only one IU campus could be affiliated with the NCAA. Thus, steps were initiated to affiliate with the NAIA. These efforts culminated with active membership being attained in 1978. In 1982, the AIAW folded and the NAIA added women's programs to the organization.
In time for the 1979-80 season, IU–Southeast added an activities building. This facility has a seating capacity of approximately 1,624. There are a number of programs available to students including intramurals, a fitness facility, and classes that focus on fitness.
For the 2006-2007 academic year, 15 IU–Southeast students were named "All Scholar Athletes" by the KIAC. Students who are awarded this honor must have maintained a 3.25 or higher GPA while attending classes full-time and have participated in one or more athletics programs. During the 2005-2006 academic year, 14 IU–Southeast students were awarded this honor as well.
The schools mascot for sporting events is a Grenadier. In the 2007-2008 academic year, IU–Southeast won the KIAC conference championship in the following sports; baseball, basketball, softball, as well as men's and women's tennis. Pat Mrozowski was named KIAC athletic director of the year.