Tuition aside, what benefits and drawbacks exist by going to school in-state vs. out-of-state?
The missing piece in this question is the specific student it applies to! The benefits and drawbacks will vary according to the student. For example, in general, going farther away from home may help a student become more self reliant in decision and action. On the other hand, some students may struggle mightily when they lose easy access to supportive family and friends back home. Often students will seek and gain employment after graduation in the city or region in which they attended college. Again, this can be a benefit or drawback depending on what the student wishes to do in their work or where they want to live in the longer term. Sometimes staying put in a region or city you love can be a very good practical decision -- it simply depends!